In Word (2008, Mac, at least) you can do a File>Save As and choose PDF. If your images in the Word doc are hi-res (300ppi), the resulting PDF may be also.
You may need to open this Word-generated PDF in Acrobat and resave with higher settings.
Better yet, don't use Word for this sort of design–use a graphics app (for instance, I use Canvas X for my and can choose the output resolution. I use 72 for the sake of file size but can use any resolution I wish). Also, Illustrator and such should work (I know you can render the whole layout as an image).
Comments and discussions about other graphics tools
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